110 http://isa.epfl.ch/imoniteur_ISAP/ itffichecours.txt?path=EPFL.Etu.FicheCours.HeaderFR itffichecours.txt?path=EPFL.Etu.FicheCours.GlobalNav_js fr 2026 2140391 2140391 2840683608 2840683608 1 0 Neurosciences (edoc) EDNE !itffichecours.htm?ww_i_matiere=2395755523&ww_x_anneeAcad=2840683608&ww_i_section=2140391&ww_i_niveau= 1696552884 1696552963 2025-2026 COURSE BOOKLET BIO-480 Neuroscience: from molecular mechanisms to disease Neuroscience: from molecular mechanisms to disease Lecturers Gräff Johannes, Mahul Mellier Anne-Laure, Schneider Bernard Language of teaching English Cursus Life Sciences Engineering(2025-2026, SV - Master 2024)
Life Sciences Engineering(2025-2026, SV - Master 2025)
Minor in life sciences engineering (2025-2026, Mineur : Sciences et technologies du vivant 2025-26)
Neuro-X minor(2025-2026, Mineur : Neuro-X 2025-26)
Neuro-X(2025-2026, SNX - Master 2024)
Neuro-X(2025-2026, SNX - Master 2025)
Neuroscience (edoc)(2025-2026, EDNE 2025-26)
SemesterMand.OptionFilières
x
Hx
MA1, MA3x
MA1, MA3xL
 Credits 5 Session Winter Workload 150h Exam Written Number of positions Semester Fall Weeks 14 Hours 5 weekly
Courses 3 weekly
Exercises 2 weekly
Study planSemesterMand.OptionFilières
EDNE - Neuroscience 2025-26x
Ingénierie des sciences du vivant 2025-26MA1xL
Ingénierie des sciences du vivant 2025-26MA3xL
Mineur : Ingénierie des Sciences du vivant 2025-26Hx
Mineur : Neuro-X 2025-26Hx
Neuro-X 2025-26MA1x
Neuro-X 2025-26MA3x
Cursus Sem. Type
Life Sciences Engineering MA1, MA3 Opt.
Minor in life sciences engineering H Opt.
Neuro-X minor H Opt.
Neuro-X MA1, MA3 Opt.
Neuroscience Opt.
Summary The goal of the course is to guide students through the essential aspects of molecular neuroscience and neurodegenerative diseases. The student will gain the ability to dissect the molecular basis of disease in the nervous system in order to begin to understand and identify therapeutic strategies. Content

 

  • Anatomical and functional organization of the brain
  • Unique biology of neurons
  • Unique biology of glial cells
  • Generation, survival and integration of nerve cells
  • Neuropharmacology
  • Aging
  • Alzheimer's disease
  • Parkinson's disease
  • Motor neuron diseases
  • Protein aggregation in neurodegenerative disease
  • Animal models of disease and translational neuroscience
  • Neuroepigenetics
 Learning Outcomes By the end of the course, the student must be able to:
  • Define key concepts in neurodegenerative diseases
  • Assess / Evaluate novel therapeutic strategies for neurodegenerative diseases
  • Compare the unique properties of neuronal and glial cells
  • Hypothesize therapeutic strategies for treating brain diseases
  • Describe he function of genes associated with neurodegenerative diseases
  • Design experiments to evaluate genetic mutations associated with neurodegenerative diseases
 Transversal skills
  • Access and evaluate appropriate sources of information.
  • Summarize an article or a technical report.
 Assessment methods

Written exam. 3 hours duration. Will contain short essay-style questions.

 Resources Bibliography

Purves, Neuroscience. 2012. 5th Ed. Sinauer Associates

Kandel, Principles of Neural Science. 2012. 5th Ed. McGraw Hill

Ressources en bibliothèque

 Ressources en bibliothèque
  • Find the references at the Libraryhttps://slsp-epfl.primo.exlibrisgroup.com/discovery/search?query=course_code,contains,%22BIO-480%202025-2026%22&tab=41SLSP_EPF_MyInst_and_CI&search_scope=MyInst_and_CI&vid=41SLSP_EPF:prod
 Moodle Link Ingénierie des sciences du vivant, 2025-2026, Master semestre 1 Life Sciences Engineering, 2025-2026, Master semester 1 Ecole polytechnique fédérale de Lausanne EPFL Ecole polytechnique fédérale de Lausanne EPFL 2025-2026 Master semestre 1 MA1 HIVER Master semester 1 MA1 Ingénierie des sciences du vivant SV Life Sciences Engineering SV
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
L optionnel optional
3 Cours Courses Heure(s) hebdo x 14 semaines Hour(s) per week x 14 weeks H hebdo H hebdo Gräff Johannes 240725
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
Schneider Bernard 150348
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
Mahul Mellier Anne-Laure 216619
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
2 Exercices Exercises Heure(s) hebdo x 14 semaines Hour(s) per week x 14 weeks H hebdo H hebdo Schneider Bernard 150348
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
Gräff Johannes 240725
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
Mahul Mellier Anne-Laure 216619
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
2395755523 Neuroscience: from molecular mechanisms to disease Neuroscience: from molecular mechanisms to disease 5
Ecrit Written Crédit Credits 5 Session hiver Session winter HIV HIV
Ingénierie des sciences du vivant, 2025-2026, Master semestre 3 Life Sciences Engineering, 2025-2026, Master semester 3 Ecole polytechnique fédérale de Lausanne EPFL Ecole polytechnique fédérale de Lausanne EPFL 2025-2026 Master semestre 3 MA3 HIVER Master semester 3 MA3 Ingénierie des sciences du vivant SV Life Sciences Engineering SV
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
L optionnel optional
3 Cours Courses Heure(s) hebdo x 14 semaines Hour(s) per week x 14 weeks H hebdo H hebdo Gräff Johannes 240725
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
Schneider Bernard 150348
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
Mahul Mellier Anne-Laure 216619
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
2 Exercices Exercises Heure(s) hebdo x 14 semaines Hour(s) per week x 14 weeks H hebdo H hebdo Schneider Bernard 150348
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
Gräff Johannes 240725
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
Mahul Mellier Anne-Laure 216619
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
2395755523 Neuroscience: from molecular mechanisms to disease Neuroscience: from molecular mechanisms to disease 5
Ecrit Written Crédit Credits 5 Session hiver Session winter HIV HIV
Neuro-X, 2025-2026, Master semestre 1 Neuro-X, 2025-2026, Master semester 1 Ecole polytechnique fédérale de Lausanne EPFL Ecole polytechnique fédérale de Lausanne EPFL 2025-2026 Master semestre 1 MA1 HIVER Master semester 1 MA1 Neuro-X NX Neuro-X NX
Neuro-X NX Neuro-X NX
optionnel optional
3 Cours Courses Heure(s) hebdo x 14 semaines Hour(s) per week x 14 weeks H hebdo H hebdo Gräff Johannes 240725
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
Schneider Bernard 150348
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
Mahul Mellier Anne-Laure 216619
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
2 Exercices Exercises Heure(s) hebdo x 14 semaines Hour(s) per week x 14 weeks H hebdo H hebdo Schneider Bernard 150348
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
Gräff Johannes 240725
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
Mahul Mellier Anne-Laure 216619
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
2395755523 Neuroscience: from molecular mechanisms to disease Neuroscience: from molecular mechanisms to disease 5
Ecrit Written Crédit Credits 5 Session hiver Session winter HIV HIV
Neuro-X, 2025-2026, Master semestre 3 Neuro-X, 2025-2026, Master semester 3 Ecole polytechnique fédérale de Lausanne EPFL Ecole polytechnique fédérale de Lausanne EPFL 2025-2026 Master semestre 3 MA3 HIVER Master semester 3 MA3 Neuro-X NX Neuro-X NX
Neuro-X NX Neuro-X NX
optionnel optional
3 Cours Courses Heure(s) hebdo x 14 semaines Hour(s) per week x 14 weeks H hebdo H hebdo Gräff Johannes 240725
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
Schneider Bernard 150348
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
Mahul Mellier Anne-Laure 216619
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
2 Exercices Exercises Heure(s) hebdo x 14 semaines Hour(s) per week x 14 weeks H hebdo H hebdo Schneider Bernard 150348
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
Gräff Johannes 240725
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
Mahul Mellier Anne-Laure 216619
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
2395755523 Neuroscience: from molecular mechanisms to disease Neuroscience: from molecular mechanisms to disease 5
Ecrit Written Crédit Credits 5 Session hiver Session winter HIV HIV
Mineur en Ingénierie des Sciences du Vivant, 2025-2026, Semestre automne Minor in life sciences engineering , 2025-2026, Autumn semester Ecole polytechnique fédérale de Lausanne EPFL Ecole polytechnique fédérale de Lausanne EPFL 2025-2026 Semestre automne H HIVER Autumn semester H Mineur en Ingénierie des Sciences du Vivant MIN_SV Minor in life sciences engineering MIN_SV
optionnel optional
3 Cours Courses Heure(s) hebdo x 14 semaines Hour(s) per week x 14 weeks H hebdo H hebdo Gräff Johannes 240725
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
Schneider Bernard 150348
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
Mahul Mellier Anne-Laure 216619
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
2 Exercices Exercises Heure(s) hebdo x 14 semaines Hour(s) per week x 14 weeks H hebdo H hebdo Schneider Bernard 150348
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
Gräff Johannes 240725
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
Mahul Mellier Anne-Laure 216619
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
2395755523 Neuroscience: from molecular mechanisms to disease Neuroscience: from molecular mechanisms to disease 5
Ecrit Written Crédit Credits 5 Session hiver Session winter HIV HIV
Mineur en Neuro-X, 2025-2026, Semestre automne Neuro-X minor, 2025-2026, Autumn semester Ecole polytechnique fédérale de Lausanne EPFL Ecole polytechnique fédérale de Lausanne EPFL 2025-2026 Semestre automne H HIVER Autumn semester H Mineur en Neuro-X MIN_NX Neuro-X minor MIN_NX
optionnel optional
3 Cours Courses Heure(s) hebdo x 14 semaines Hour(s) per week x 14 weeks H hebdo H hebdo Gräff Johannes 240725
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
Schneider Bernard 150348
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
Mahul Mellier Anne-Laure 216619
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
2 Exercices Exercises Heure(s) hebdo x 14 semaines Hour(s) per week x 14 weeks H hebdo H hebdo Gräff Johannes 240725
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
Schneider Bernard 150348
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
Mahul Mellier Anne-Laure 216619
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
2395755523 Neuroscience: from molecular mechanisms to disease Neuroscience: from molecular mechanisms to disease 5
Ecrit Written Crédit Credits 5 Session hiver Session winter HIV HIV
Neurosciences (edoc), 2025-2026 Neuroscience (edoc), 2025-2026 Ecole polytechnique fédérale de Lausanne EPFL Ecole polytechnique fédérale de Lausanne EPFL 2025-2026 Neurosciences (edoc) EDNE Neuroscience (edoc) EDNE
optionnel optional
3 Cours Courses Heure(s) hebdo x 14 semaines Hour(s) per week x 14 weeks H hebdo H hebdo Gräff Johannes 240725
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
Schneider Bernard 150348
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
Mahul Mellier Anne-Laure 216619
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
2 Exercices Exercises Heure(s) hebdo x 14 semaines Hour(s) per week x 14 weeks H hebdo H hebdo Schneider Bernard 150348
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
Gräff Johannes 240725
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
Mahul Mellier Anne-Laure 216619
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
2395755523 Neuroscience: from molecular mechanisms to disease Neuroscience: from molecular mechanisms to disease 5
Ecrit Written Crédit Credits 5 Session hiver Session winter HIV HIV
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