110 http://isa.epfl.ch/imoniteur_ISAP/ itffichecours.txt?path=EPFL.Etu.FicheCours.HeaderFR itffichecours.txt?path=EPFL.Etu.FicheCours.GlobalNav_js fr 2026 944263 6683147 944263 2305107546 2305107546 0 0 Genie mecanique GM STI Faculté des sciences et techniques de l'ingénieur School of Engineering !itffichecours.htm?ww_i_matiere=2916474443&ww_x_anneeAcad=2305107546&ww_i_section=944263&ww_i_niveau=6683147 1696552884 1696552963 2024-2025 COURSE BOOKLET ME-480 Mechanobiology: how mechanics regulate life Mechanobiology: how mechanics regulate life Lecturers Persat Alexandre, Sakar Selman Language of teaching English Cursus Biomedical technologies minor(2024-2025, Mineur : Technologies biomédicales 2024-25)
Life Sciences Engineering(2024-2025, SV - Master 2023)
Life Sciences Engineering(2024-2025, SV - Master 2024)
Mechanical Engineering(2024-2025, GM - Master 2023)
Mechanical Engineering(2024-2025, GM - Master 2024)
Mechanical engineering minor(2024-2025, Mineur : Génie mécanique 2024-25)
Minor in life sciences engineering (2024-2025, Mineur : Sciences et technologies du vivant 2024-25)
Physics of living systems minor(2024-2025, Mineur : Physique des systèmes vivants 2024-25)
SemesterMand.OptionFilières
Hx
MA1, MA3x
MA1, MA3xF
 Credits 4 Withdrawal Unauthorized It is not allowed to withdraw from this subject after the registration deadline. Session Winter Workload 120h Exam During the semester Number of positions Il n'est pas autorisé de se retirer de cette matière après le délai d'inscription. Semester Fall Weeks 14 Hours 4 weekly
Courses 2 weekly
Exercises 2 weekly
Study planSemesterMand.OptionFilières
Génie mécanique 2024-25MA1xF
Génie mécanique 2024-25MA3xF
Ingénierie des sciences du vivant 2024-25MA1x
Ingénierie des sciences du vivant 2024-25MA3x
Mineur : Génie mécanique 2024-25Hx
Mineur : Ingénierie des Sciences du vivant 2024-25Hx
Mineur : Physique des systèmes vivants 2024-25Hx
Mineur : Technologies biomédicales 2024-25Hx
Cursus Sem. Type
Biomedical technologies minor H Opt.
Life Sciences Engineering MA1, MA3 Opt.
Mechanical engineering minor H Opt.
Mechanical engineering MA1, MA3 Opt.
Minor in life sciences engineering H Opt.
Physics of living systems minor H Opt.
Summary The objective of this course is to expose students to the fundamentals of mechanobiology. We will highlight the technologies that enable the study of living systems including mechanical manipulation and characterization, along with computational modeling frameworks. Content

The course will cover the micro/nanoscale physics, biological mechanosensors and actuators, motility, extracellular matrix mechanics, tissue and cell mechanics, morphogenesis, and control issues. After providing the basic background, we will explore the current trends in the literature, discuss select case studies, and develop conceptual novel solutions for outstanding issues. The course will be divided into the following sections:

  • Mechanobiology of microbes and biofilms.
  • Mechanobiology during infections
  • Mechanobiology of plant cells and tissues
  • Fundamentals of mechanotransduction (cytoskeleton, nucleus, and signaling)
  • Mechanobiology of immune cells and tumors
  • Mechanobiology of morphogenesis and regeneration
  • Synthetic morphogenesis and biomimetic culture systems
 Keywords

mechanosensing, mechanotransduction, physics of living systems, solid mechanics, fluid mechanics, bioinstrumentation, quantitative microscopy, microtechnology, robotic biomanipulation.

 

 Learning Prerequisites Recommended courses

Biomaterials (BIOENG-442)

Physics of Cells (BIO-244)

 Learning Outcomes By the end of the course, the student must be able to:
  • Propose mechanical tests for the characterization of biological tissues and fluids, B6
  • Describe the feedback loop that, starting from a mechanical signal translated into a chemical signal, allows for the adaptation of the mechanical properties of tissues, B9
  • Develop physical models of living systems
  • Synthesize learned engineering skills to create novel solutions, CP14
  • Specify the role of mechanics in a particular physiological or pathological process
 Transversal skills
  • Make an oral presentation.
  • Summarize an article or a technical report.
  • Write a scientific or technical report.
  • Access and evaluate appropriate sources of information.
  • Evaluate one's own performance in the team, receive and respond appropriately to feedback.
 Teaching methods
  • Ex cathedra
  • Interactive presentations of case studies by graduate students
  • Exercises
  • Student Presentations
 Expected student activities
  • Active participation
  • Reading background literature
  • Critical evaluation of technical articles and group presentations
  • Writing a report
 Assessment methods
  • Literature Review Report (25%)
  • Assignments (25%)
  • Final Project (50%)
 Supervision Office hours No Assistant.e.s Yes Forum Yes Resources Bibliography
  • Physical Biology of the Cell, by Rob Philipps and collegaues. Garland Science (2nd edition).
  • Mechanisms of Morphogenesis, by Jamie A. Davies. Academic Press (2nd edition).
  • Biological Physics of the Developing Embryo by Gabor Forgacs and Stuart A. Newman. Cambridge University Press.
 Moodle Link Génie mécanique, 2024-2025, Master semestre 1 Mechanical Engineering, 2024-2025, Master semester 1 Ecole polytechnique fédérale de Lausanne EPFL Ecole polytechnique fédérale de Lausanne EPFL 2024-2025 Master semestre 1 MA1 HIVER Master semester 1 MA1 Génie mécanique GM Mechanical Engineering GM
Génie mécanique GM Mechanical Engineering GM
F optionnel optional
2 Cours Courses Heure(s) hebdo x 14 semaines Hour(s) per week x 14 weeks H hebdo H hebdo Persat Alexandre Louis André 270835
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
Sakar Mahmut Selman 265227
Génie mécanique GM Mechanical Engineering GM
2 Exercices Exercises Heure(s) hebdo x 14 semaines Hour(s) per week x 14 weeks H hebdo H hebdo Persat Alexandre Louis André 270835
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
Sakar Mahmut Selman 265227
Génie mécanique GM Mechanical Engineering GM
2916474443 Mechanobiology: how mechanics regulate life Mechanobiology: how mechanics regulate life 4
Pendant le semestre During the semester Crédit Credits 4 Session hiver Session winter HIV HIV
Génie mécanique, 2024-2025, Master semestre 3 Mechanical Engineering, 2024-2025, Master semester 3 Ecole polytechnique fédérale de Lausanne EPFL Ecole polytechnique fédérale de Lausanne EPFL 2024-2025 Master semestre 3 MA3 HIVER Master semester 3 MA3 Génie mécanique GM Mechanical Engineering GM
Génie mécanique GM Mechanical Engineering GM
F optionnel optional
2 Cours Courses Heure(s) hebdo x 14 semaines Hour(s) per week x 14 weeks H hebdo H hebdo Persat Alexandre Louis André 270835
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
Sakar Mahmut Selman 265227
Génie mécanique GM Mechanical Engineering GM
2 Exercices Exercises Heure(s) hebdo x 14 semaines Hour(s) per week x 14 weeks H hebdo H hebdo Persat Alexandre Louis André 270835
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
Sakar Mahmut Selman 265227
Génie mécanique GM Mechanical Engineering GM
2916474443 Mechanobiology: how mechanics regulate life Mechanobiology: how mechanics regulate life 4
Pendant le semestre During the semester Crédit Credits 4 Session hiver Session winter HIV HIV
Ingénierie des sciences du vivant, 2024-2025, Master semestre 1 Life Sciences Engineering, 2024-2025, Master semester 1 Ecole polytechnique fédérale de Lausanne EPFL Ecole polytechnique fédérale de Lausanne EPFL 2024-2025 Master semestre 1 MA1 HIVER Master semester 1 MA1 Ingénierie des sciences du vivant SV Life Sciences Engineering SV
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
optionnel optional
2 Cours Courses Heure(s) hebdo x 14 semaines Hour(s) per week x 14 weeks H hebdo H hebdo Persat Alexandre Louis André 270835
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
Sakar Mahmut Selman 265227
Génie mécanique GM Mechanical Engineering GM
2 Exercices Exercises Heure(s) hebdo x 14 semaines Hour(s) per week x 14 weeks H hebdo H hebdo Persat Alexandre Louis André 270835
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
Sakar Mahmut Selman 265227
Génie mécanique GM Mechanical Engineering GM
2916474443 Mechanobiology: how mechanics regulate life Mechanobiology: how mechanics regulate life 4
Pendant le semestre During the semester Crédit Credits 4 Session hiver Session winter HIV HIV
Ingénierie des sciences du vivant, 2024-2025, Master semestre 3 Life Sciences Engineering, 2024-2025, Master semester 3 Ecole polytechnique fédérale de Lausanne EPFL Ecole polytechnique fédérale de Lausanne EPFL 2024-2025 Master semestre 3 MA3 HIVER Master semester 3 MA3 Ingénierie des sciences du vivant SV Life Sciences Engineering SV
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
optionnel optional
2 Cours Courses Heure(s) hebdo x 14 semaines Hour(s) per week x 14 weeks H hebdo H hebdo Persat Alexandre Louis André 270835
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
Sakar Mahmut Selman 265227
Génie mécanique GM Mechanical Engineering GM
2 Exercices Exercises Heure(s) hebdo x 14 semaines Hour(s) per week x 14 weeks H hebdo H hebdo Persat Alexandre Louis André 270835
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
Sakar Mahmut Selman 265227
Génie mécanique GM Mechanical Engineering GM
2916474443 Mechanobiology: how mechanics regulate life Mechanobiology: how mechanics regulate life 4
Pendant le semestre During the semester Crédit Credits 4 Session hiver Session winter HIV HIV
Mineur en Génie mécanique, 2024-2025, Semestre automne Mechanical engineering minor, 2024-2025, Autumn semester Ecole polytechnique fédérale de Lausanne EPFL Ecole polytechnique fédérale de Lausanne EPFL 2024-2025 Semestre automne H HIVER Autumn semester H Mineur en Génie mécanique MIN_GM Mechanical engineering minor MIN_GM
optionnel optional
2 Cours Courses Heure(s) hebdo x 14 semaines Hour(s) per week x 14 weeks H hebdo H hebdo Persat Alexandre Louis André 270835
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
Sakar Mahmut Selman 265227
Génie mécanique GM Mechanical Engineering GM
2 Exercices Exercises Heure(s) hebdo x 14 semaines Hour(s) per week x 14 weeks H hebdo H hebdo Persat Alexandre Louis André 270835
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
Sakar Mahmut Selman 265227
Génie mécanique GM Mechanical Engineering GM
2916474443 Mechanobiology: how mechanics regulate life Mechanobiology: how mechanics regulate life 4
Pendant le semestre During the semester Crédit Credits 4 Session hiver Session winter HIV HIV
Mineur en Ingénierie des Sciences du Vivant, 2024-2025, Semestre automne Minor in life sciences engineering , 2024-2025, Autumn semester Ecole polytechnique fédérale de Lausanne EPFL Ecole polytechnique fédérale de Lausanne EPFL 2024-2025 Semestre automne H HIVER Autumn semester H Mineur en Ingénierie des Sciences du Vivant MIN_SV Minor in life sciences engineering MIN_SV
optionnel optional
2 Cours Courses Heure(s) hebdo x 14 semaines Hour(s) per week x 14 weeks H hebdo H hebdo Persat Alexandre Louis André 270835
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
Sakar Mahmut Selman 265227
Génie mécanique GM Mechanical Engineering GM
2 Exercices Exercises Heure(s) hebdo x 14 semaines Hour(s) per week x 14 weeks H hebdo H hebdo Persat Alexandre Louis André 270835
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
Sakar Mahmut Selman 265227
Génie mécanique GM Mechanical Engineering GM
2916474443 Mechanobiology: how mechanics regulate life Mechanobiology: how mechanics regulate life 4
Pendant le semestre During the semester Crédit Credits 4 Session hiver Session winter HIV HIV
Mineur en Physique des systèmes vivants, 2024-2025, Semestre automne Physics of living systems minor, 2024-2025, Autumn semester Ecole polytechnique fédérale de Lausanne EPFL Ecole polytechnique fédérale de Lausanne EPFL 2024-2025 Semestre automne H HIVER Autumn semester H Mineur en Physique des systèmes vivants MIN_SV_PHYS Physics of living systems minor MIN_SV_PHYS
optionnel optional
2 Cours Courses Heure(s) hebdo x 14 semaines Hour(s) per week x 14 weeks H hebdo H hebdo Persat Alexandre Louis André 270835
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
Sakar Mahmut Selman 265227
Génie mécanique GM Mechanical Engineering GM
2 Exercices Exercises Heure(s) hebdo x 14 semaines Hour(s) per week x 14 weeks H hebdo H hebdo Persat Alexandre Louis André 270835
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
Sakar Mahmut Selman 265227
Génie mécanique GM Mechanical Engineering GM
2916474443 Mechanobiology: how mechanics regulate life Mechanobiology: how mechanics regulate life 4
Pendant le semestre During the semester Crédit Credits 4 Session hiver Session winter HIV HIV
Mineur en Technologies biomédicales, 2024-2025, Semestre automne Biomedical technologies minor, 2024-2025, Autumn semester Ecole polytechnique fédérale de Lausanne EPFL Ecole polytechnique fédérale de Lausanne EPFL 2024-2025 Semestre automne H HIVER Autumn semester H Mineur en Technologies biomédicales MIN_BIOMED Biomedical technologies minor MIN_BIOMED
optionnel optional
2 Cours Courses Heure(s) hebdo x 14 semaines Hour(s) per week x 14 weeks H hebdo H hebdo Persat Alexandre Louis André 270835
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
Sakar Mahmut Selman 265227
Génie mécanique GM Mechanical Engineering GM
2 Exercices Exercises Heure(s) hebdo x 14 semaines Hour(s) per week x 14 weeks H hebdo H hebdo Persat Alexandre Louis André 270835
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
Sakar Mahmut Selman 265227
Génie mécanique GM Mechanical Engineering GM
2916474443 Mechanobiology: how mechanics regulate life Mechanobiology: how mechanics regulate life 4
Pendant le semestre During the semester Crédit Credits 4 Session hiver Session winter HIV HIV
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