The students will be introduced in the physiology and pathophysiology of core neurological and mental disorders, such as e.g., stroke, TBI, spinal cord injury or neurodegenerative disorders, followed by aspects of respective clinical translational, technological development and neuroengineering in these clinical domains and important regulatory, neuroethical and R&D points. The course content is organized as follows. Each week 2 x 1.5 h lectures and 3h exercise.

Lecture topics:

Memory-Learning: Physiology (FH)

Dementia: Background/Pathophysiology (FH)

Motor cortical functioning: Physiology (FH)

Stroke: Background/Pathophysiology (FH)

Cognitive Functioning (Attention, frontal-executive, language): Physiology (FH)

Traumatic Brain Injury, Stroke: Background/Pathophysiology (FH)

Technology- Non-invasive brain stimulation (NIBS): Introduction in Methods and Concepts (FH)

Technology-Translation Stroke, TBI: NIBS technology (TMS, tES, TI) in stroke and dementia (FH)

Visual, auditory functioning: Physiology (SM/FH)

Pre-, postchiasmatic visual deficits (e.g., retinitis pigmentosa, congenital deafness): Background/Pathophysiology (SM/FH)

Technology- Perceptual prosthetics: Introduction in Methods and Concepts (SM)

Technology - Translation Perceptual deficits: Retinal and acoustic prothesis in perceptual disorders (SM)

Peripheral, central sensorimotor processing: Physiology, Background and Pathophysiology (Amputees) (SM)

Technology - Translation Amputees: Bionic Hand, limb prosthetics (SM)

Spinal functioning: Physiology (GC)

Spinal cord injury (SCI): Background/Pathophysiology (GC)

Technology - Closed loop spinal neuromodulation: Introduction in Methods and Concepts (GC)

Technology - Translation SCI, MSA: Therapy of gait impairment, deficits in blood pressure modulation (GC)

Extrapyramidal control, functioning: Physiology (OB)

Extrapyramidal disorders (Parkinson's disease): Background/Pathophysiology (OB)

Technology - deep brain stimulation (DBS): Introduction in Methods and Concepts (OB)

Technology - Translation Parkinson's: DBS and focused ultrasound to treat Parkinson's symptoms (OB)

Somatosensory functioning, perceptual integration: Physiology, Background and Pathophysiology (Hallucinations) (OB)

Technology - Translation Hallucinations: Virtual reality-based technology to address hallucinations (OB)

Personalized Medicine: General Concepts of Personalized Medicine (FH)

Neuroethics: Introduction in Neuroethics (FH + ext lecturer)

Regulatory towards the Clinical Market: Introduction in important regulatory aspects (GC + ext lecturer)

Start-up: Introduction in steps towards and realities in a start-up in Neurotechnology (SM + ext lecturer)

- translational neuroengineering and neurotechnology

- personalized medicine

- cognition

- sensorimotor processing

- perceptional processing

- pathophysiology of neurological and mental disorders

- basic, systems, computational translational neuroscience

- Regulatory, clinical trials

- start-up

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-       Computational motor control

-       Neuroengineering on vision

-       Haptic human robot interfaces

-       Machine Learning for behavioral data

-       VR

-       Understanding statistics and experimental design (and/or Applied biostatistics)

-       Machine Learning for behavioral data

-       Biomedical signal processing

-       Scientific project design in translational neuroscience

- Basics in sensorimotor, perceptional and cognitive processing.

- Basics in statistics and experimental design

- 'From Bench to bedside' concept

• Contextualise
• Assess / Evaluate
• Discuss
• Present
• Reason
• Hypothesize
• Plan
• Explain

• Respect relevant legal guidelines and ethical codes for the profession.
• Take account of the social and human dimensions of the engineering profession.
• Demonstrate a capacity for creativity.
• Demonstrate the capacity for critical thinking
• Communicate effectively with professionals from other disciplines.
• Summarize an article or a technical report.
• Use a work methodology appropriate to the task.
• Access and evaluate appropriate sources of information.

Interactive Lectures, Exercise

Preparation of lectures including suggested literature review

Active Participation in Lectures

Active participation in exercises

Written Final Exam (MCQ+Report): 60%

Project Presentations and evaluations: 40%

Textbooks for preparation e.g. for Neuromodulation, Neuroscience, Neuroengineering or Neuroprosthetics e.g., Textbook of Neuromodulation (Knotkova, Rasche, Springer New York), Principles of Neural Science (Kandel et al., MCGRAW-HILL Higher Education), Neuroscience: Exploring The Brain, Enhanced Edition (Connors et al. Jones and Bartlett Publishers, Inc), Principles of Cognitive Neuroscience (Purves et al. Oxford University Press), Neuroprosthetics, Principles and Applications (Sanchez, CRC Press), Handbook of Neuroengineering (N. V. Thakor (ed.), Springer Nature Singapore Pte Ltd. 2022)

• Find the references at the Libraryhttps://slsp-epfl.primo.exlibrisgroup.com/discovery/search?query=course_code,contains,%22NX-423%202025-2026%22&tab=41SLSP_EPF_MyInst_and_CI&search_scope=MyInst_and_CI&vid=41SLSP_EPF:prod

will be provided before the course

• https://go.epfl.ch/NX-423https://go.epfl.ch/NX-423