Introduction and key concepts.

• The Human Body. The Nervous System.
• Scales. Biomaterials. Biomechanics.
• Functions. Electrophysiology.
• Neural Recording.
• Communication. Standards.

Clinical implants for neuromodulation.

• Electrodes and leads: materials, manufacturing, electrochemical impedance spectrocopy
• Function: neuromodulation: Stimulation parameters.
• Implantable neural system: Packaging.

Brain Computer Interfaces.

• Invasive and wearable technologies.
• Electrodes. Scale and density.
• Metallic (macroscopic) electrodes.
• Silicon-based (micromachined) electrodes.
• Flexible probes
• Multimodal probes
• Biointegration

Implantable electronics.

• Miniaturized CMOS-based interfaces
• Neural amplifiers
• Digitization and compression methods and circuits
• Neurostimulation methods and circuits
• Classification of neural data
• BCI systems
• Spike sorting, decoding and control
• Wireless power and data transmission

By the end of the course, students will be able to design, analyze, and critically evaluate neural interface systems by integrating knowledge of neural physiology, bioelectronics, circuit design, and signal processing, with applications ranging from neuroscience research to clinical neuroprosthetics.

Electrodes

Microfabrication

Biomaterials

Implantable electronics

Circuit design

Low-power electronics

Machine learning

Telemetry

Neural Engineering

Basic circuit analysis, Basic electronics

par example, EE-295, EE-296

Background in electronics e.g. EE-202, EE-203, EE-295, EE-296

Analog IC design EE-320

Sensors MICRO-330, Microfabrication e.g. MICRO-301, MICRO-331

Materials MSE-207, MSE-208, BIO315

Background in neuroscience BIO311

Basic concepts in electronics and circuit analysis

• Design
• Develop
• Sketch
• Integrate
• Propose
• Plan

• Communicate effectively, being understood, including across different languages and cultures.
• Keep appropriate documentation for group meetings.
• Give feedback (critique) in an appropriate fashion.
• Make an oral presentation.
• Write a scientific or technical report.

Ex cathedra lectures

In-class Exercices (once a month)

Team project (throughout the semester)

attend weekly lectures

read proposed references

develop a team project

Assessment will be completed entirely during the semester (Semester Branch).

1. in-class evaluation (40%)

two (2x20%) in-class, graded tests, closed book

2. Team project (60%)

project report (40%)

team oral presentation (20%)

Books:

Neuroprosthetics: Theory and Practice (Second Edition)

K.Horch, D. Kipke

Design of Analog CMOS Integrated Circuits, 2nd Edition, B. Razavi, McGraw-Hill

• Find the references at the Libraryhttps://slsp-epfl.primo.exlibrisgroup.com/discovery/search?query=course_code,contains,%22NX-422%202025-2026%22&tab=41SLSP_EPF_MyInst_and_CI&search_scope=MyInst_and_CI&vid=41SLSP_EPF:prod

lecture slides on moodle

• https://go.epfl.ch/NX-422https://go.epfl.ch/NX-422