110 http://isa.epfl.ch/imoniteur_ISAP/ itffichecours.txt?path=EPFL.Etu.FicheCours.HeaderFR itffichecours.txt?path=EPFL.Etu.FicheCours.GlobalNav_js fr 2026 246696 6683147 246696 2305107546 2305107546 0 0 Chimie et genie chimique CGC SB Faculté des sciences de base School of Basic Sciences !itffichecours.htm?ww_i_matiere=71898059&ww_x_anneeAcad=2305107546&ww_i_section=246696&ww_i_niveau=6683147 1696552884 1696552963 2024-2025 COURSE BOOKLET ChE-411 Principles and applications of systems biology Principles and applications of systems biology Lecturers Hatzimanikatis Vassily Language of teaching English Cursus Biotechnology minor(2024-2025, Mineur : Biotechnologie 2024-25)
Chemical Engineering and Biotechnology(2024-2025, CGC - Master 2023 ing.-chim )
Chemical Engineering and Biotechnology(2024-2025, CGC - Master 2024 ing.-chim )
Computational biology minor(2024-2025, Mineur : Computational Biology 2024-25)
Computational science and Engineering(2024-2025, MA-CO - Master 2023)
Computational science and Engineering(2024-2025, MA-CO - Master 2024)
Computational science and engineering minor(2024-2025, Mineur : Science et ingénierie computationnelles 2024-25)
Life Sciences Engineering(2024-2025, SV - Master 2023)
Life Sciences Engineering(2024-2025, SV - Master 2024)
Physics of living systems minor(2024-2025, Mineur : Physique des systèmes vivants 2024-25)
Systems Engineering minor(2024-2025, Mineur : Systems Engineering 2024-25)
SemesterMand.OptionFilières
Hx
MA1, MA3x
MA1, MA3xA
MA1, MA3xK
 Credits 3 Session Winter Workload 90h Exam During the semester Number of positions Semester Fall Weeks 14 Hours 3 weekly
Courses 2 weekly
Exercises 1 weekly
Study planSemesterMand.OptionFilières
Génie chimique et biotechnologie 2024-25MA1x
Génie chimique et biotechnologie 2024-25MA3x
Ingénierie des sciences du vivant 2024-25MA1xK
Ingénierie des sciences du vivant 2024-25MA3xK
Mineur : Biotechnologie 2024-25Hx
Mineur : Computational biology 2024-25Hx
Mineur : Physique des systèmes vivants 2024-25Hx
Mineur : Science et ing. computationnelles 2024-25Hx
Mineur : Systems engineering 2024-25Hx
Science et ingénierie computationelles 2024-25MA1xA
Science et ingénierie computationelles 2024-25MA3xA
Cursus Sem. Type
Biotechnology minor H Opt.
Computational biology minor H Opt.
Computational science and Engineering MA1, MA3 Opt.
Computational science and engineering minor H Opt.
Ing.-chim. MA1, MA3 Opt.
Life Sciences Engineering MA1, MA3 Opt.
Physics of living systems minor H Opt.
Systems Engineering minor H Opt.
Summary The course introduces and develops the key concepts from systems biology and systems engineering in the context of complex biological networks. The lectures elaborate on techniques and methods to model and analyze complex biological problems. Content

The topics of the course include:

  • Mathematical and computational analysis of metabolic reaction networks
  • Analysis of metabolomics and bioenergetics data in the context metabolic networks
  • Mathematical and computational analysis of protein expression
  • Methods and technologies for the analysis of signaling networks
  • Mathematical and computational analysis of DNA-protein interaction data
  • Interpretation and analysis of single cell data
  • Mathematical modeling of spatial effects in biological systems

Therefore, the course will introduce the following methods:

  • Metabolic Flux balance analysis (FBA) (Linear programming)
  • Thermodynamics based flux balance analysis (TFA) of metabolic networks (Mixed-integer linear programing).
  • Kinetic models (Ordinary differential equations)
  • Metabolic control analysis (Local and global sensitivity analysis)
  • Stochastic simulation algorithm (SSA) and Particle based simulation methods (stochastic simulation)
  • Parameter estimation for biological systems (System identification methods)

Part of the course is a computer laboratory were these methods are applied to characteristic problems.

 Keywords

Systems biology, system engineering, metabolic networks, omics-data, thermodynamics, metabolc engineering, stochastic modeling, agent-based modeling, particle-based modeling, parameter estimation.

 Learning Prerequisites Required courses

Analysis I-III, linear algebra, probability and statistics, physical chemistry, programming essentials.

 Recommended courses

The building of working groups will make it possible for people with partial knowledge in these fields to contribute depending on their formation.

 

For deeper understanding into the methods thought in this class we recommend the following courses:

 

SV courses:

  • Dynamical systems in biology BIO-341 (Naef)
  • Numerical analysis MATH-251(Deparis)

 

ChemE courses:

  • Dynamics and kinetics CH-310 (Lorenz)
  • Biochemical engineering ChE-311(Crelier, Zinn)
  • Bioreactor modeling and simulation ChE-320 (Hatzimanikatis)
  • Numerical methods ChE-312 (Miskovic, Sivula)
 Important concepts to start the course

For the computational exercises, MATLAB® and PYTHON will be the platforms of choice.

An introductory session on and the platforms and software used is part of the course.

 Learning Outcomes By the end of the course, the student must be able to:
  • Formulate mass balances of reaction networks
  • Solve mass balance equations using linear programing solvers
  • Analyze papers on modeling and analysis of biological networks
  • Assess / Evaluate alternative methods for the study of biological networks
  • Construct kinetic models of biological reactions
  • Assess / Evaluate alternative methods for the study of biological networks
  • Construct kinetic models of biological reactions
  • Create and analyze stochastic models of biological reactions
  • Analyze papers on modeling and analysis of biological networks
 Transversal skills
  • Plan and carry out activities in a way which makes optimal use of available time and other resources.
  • Access and evaluate appropriate sources of information.
  • Summarize an article or a technical report.
  • Demonstrate the capacity for critical thinking
  • Negotiate effectively within the group.
 Teaching methods

Teaching in classroom, paper reviews, project.

 Expected student activities

Presentations and critical analysis of papers.

Project.

 Assessment methods

- Exercises (50%)

- Final project presentation (50%)

 Supervision Forum No Resources Bibliography

Bibliography Primary and recommended

A First course in Systems Biology, Eberhard O. Voit 2012.

 

Systems Biology, By Edda Klipp et al. Wiley-Blackwell 2009.

 

Fundamentals of Systems Biology: From Synthetic Circuits to Whole-Cell Models, by Markus Covert

 

Modeling Differential Equations in Biology, by Clifford H. Taubes. Prentice Hall 2000.

 

An Invitation to Biomathematics, Raina Robeva James Kirkwood Robin Davies Leon Farhy Boris Kovatchev Martin Straume Michael Johnson

 

Foundations of System Biology, Edited by Hiraoki Kitano. MIT Press 2001

 

An Introduction to Systems Biology: Design Principles of Biological Circuits, by Uri Alon. Chapman and Hall/CRC 2006.

 

Computational Modeling of Genetic and Biochemical Networks, by James M. Bower and Hamid Bolouri. Bradford 2004.

 Ressources en bibliothèque
  • An Introduction to Systems Biology / Alonhttp://library.epfl.ch/en/beast?isbn=1439837171
  • Modeling differential equations in biology / Taubeshttp://library.epfl.ch/en/beast?isbn=9780521708432
  • A first course in systems biology / Voitthttp://library.epfl.ch/en/beast?isbn=1351332937
  • Computational Modeling of Genetic and Biochemical Networks / Jameshttp://library.epfl.ch/en/beast?isbn=0262024810
  • Foundations of System Biology / Nagasaki http://library.epfl.ch/en/beast?isbn=9781848820227
  • Systems Biology in Practice / Klipphttp://library.epfl.ch/en/beast?isbn=9783527310784
 Moodle Link Génie chimique et biotechnologie, 2024-2025, Master semestre 1 Chemical Engineering and Biotechnology, 2024-2025, Master semester 1 Ecole polytechnique fédérale de Lausanne EPFL Ecole polytechnique fédérale de Lausanne EPFL 2024-2025 Master semestre 1 MA1 HIVER Master semester 1 MA1 Génie chimique et biotechnologie CGC_ING Chemical Engineering and Biotechnology CGC_ING
Chimie et génie chimique CGC Chemistry and Chemical Engineering CGC
optionnel optional
2 Cours Courses Heure(s) hebdo x 14 semaines Hour(s) per week x 14 weeks H hebdo H hebdo Hatzimanikatis Vassily 174688
Chimie et génie chimique CGC Chemistry and Chemical Engineering CGC
1 Exercices Exercises Heure(s) hebdo x 14 semaines Hour(s) per week x 14 weeks H hebdo H hebdo Hatzimanikatis Vassily 174688
Chimie et génie chimique CGC Chemistry and Chemical Engineering CGC
71898059 Principles and applications of systems biology Principles and applications of systems biology 3
Pendant le semestre During the semester Crédit Credits 3 Session hiver Session winter HIV HIV
Génie chimique et biotechnologie, 2024-2025, Master semestre 3 Chemical Engineering and Biotechnology, 2024-2025, Master semester 3 Ecole polytechnique fédérale de Lausanne EPFL Ecole polytechnique fédérale de Lausanne EPFL 2024-2025 Master semestre 3 MA3 HIVER Master semester 3 MA3 Génie chimique et biotechnologie CGC_ING Chemical Engineering and Biotechnology CGC_ING
Chimie et génie chimique CGC Chemistry and Chemical Engineering CGC
optionnel optional
2 Cours Courses Heure(s) hebdo x 14 semaines Hour(s) per week x 14 weeks H hebdo H hebdo Hatzimanikatis Vassily 174688
Chimie et génie chimique CGC Chemistry and Chemical Engineering CGC
1 Exercices Exercises Heure(s) hebdo x 14 semaines Hour(s) per week x 14 weeks H hebdo H hebdo Hatzimanikatis Vassily 174688
Chimie et génie chimique CGC Chemistry and Chemical Engineering CGC
71898059 Principles and applications of systems biology Principles and applications of systems biology 3
Pendant le semestre During the semester Crédit Credits 3 Session hiver Session winter HIV HIV
Ingénierie des sciences du vivant, 2024-2025, Master semestre 1 Life Sciences Engineering, 2024-2025, Master semester 1 Ecole polytechnique fédérale de Lausanne EPFL Ecole polytechnique fédérale de Lausanne EPFL 2024-2025 Master semestre 1 MA1 HIVER Master semester 1 MA1 Ingénierie des sciences du vivant SV Life Sciences Engineering SV
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
K optionnel optional
2 Cours Courses Heure(s) hebdo x 14 semaines Hour(s) per week x 14 weeks H hebdo H hebdo Hatzimanikatis Vassily 174688
Chimie et génie chimique CGC Chemistry and Chemical Engineering CGC
1 Exercices Exercises Heure(s) hebdo x 14 semaines Hour(s) per week x 14 weeks H hebdo H hebdo Hatzimanikatis Vassily 174688
Chimie et génie chimique CGC Chemistry and Chemical Engineering CGC
71898059 Principles and applications of systems biology Principles and applications of systems biology 3
Pendant le semestre During the semester Crédit Credits 3 Session hiver Session winter HIV HIV
Ingénierie des sciences du vivant, 2024-2025, Master semestre 3 Life Sciences Engineering, 2024-2025, Master semester 3 Ecole polytechnique fédérale de Lausanne EPFL Ecole polytechnique fédérale de Lausanne EPFL 2024-2025 Master semestre 3 MA3 HIVER Master semester 3 MA3 Ingénierie des sciences du vivant SV Life Sciences Engineering SV
Ingénierie des sciences du vivant SV Life Sciences Engineering SV
K optionnel optional
2 Cours Courses Heure(s) hebdo x 14 semaines Hour(s) per week x 14 weeks H hebdo H hebdo Hatzimanikatis Vassily 174688
Chimie et génie chimique CGC Chemistry and Chemical Engineering CGC
1 Exercices Exercises Heure(s) hebdo x 14 semaines Hour(s) per week x 14 weeks H hebdo H hebdo Hatzimanikatis Vassily 174688
Chimie et génie chimique CGC Chemistry and Chemical Engineering CGC
71898059 Principles and applications of systems biology Principles and applications of systems biology 3
Pendant le semestre During the semester Crédit Credits 3 Session hiver Session winter HIV HIV
Science et ingénierie computationnelles, 2024-2025, Master semestre 1 Computational science and Engineering, 2024-2025, Master semester 1 Ecole polytechnique fédérale de Lausanne EPFL Ecole polytechnique fédérale de Lausanne EPFL 2024-2025 Master semestre 1 MA1 HIVER Master semester 1 MA1 Science et ingénierie computationnelles MA_CO Computational science and Engineering MA_CO
Mathématiques MA Mathematics MA
A optionnel optional
2 Cours Courses Heure(s) hebdo x 14 semaines Hour(s) per week x 14 weeks H hebdo H hebdo Hatzimanikatis Vassily 174688
Chimie et génie chimique CGC Chemistry and Chemical Engineering CGC
1 Exercices Exercises Heure(s) hebdo x 14 semaines Hour(s) per week x 14 weeks H hebdo H hebdo Hatzimanikatis Vassily 174688
Chimie et génie chimique CGC Chemistry and Chemical Engineering CGC
71898059 Principles and applications of systems biology Principles and applications of systems biology 3
Pendant le semestre During the semester Crédit Credits 3 Session hiver Session winter HIV HIV
Science et ingénierie computationnelles, 2024-2025, Master semestre 3 Computational science and Engineering, 2024-2025, Master semester 3 Ecole polytechnique fédérale de Lausanne EPFL Ecole polytechnique fédérale de Lausanne EPFL 2024-2025 Master semestre 3 MA3 HIVER Master semester 3 MA3 Science et ingénierie computationnelles MA_CO Computational science and Engineering MA_CO
Mathématiques MA Mathematics MA
A optionnel optional
2 Cours Courses Heure(s) hebdo x 14 semaines Hour(s) per week x 14 weeks H hebdo H hebdo Hatzimanikatis Vassily 174688
Chimie et génie chimique CGC Chemistry and Chemical Engineering CGC
1 Exercices Exercises Heure(s) hebdo x 14 semaines Hour(s) per week x 14 weeks H hebdo H hebdo Hatzimanikatis Vassily 174688
Chimie et génie chimique CGC Chemistry and Chemical Engineering CGC
71898059 Principles and applications of systems biology Principles and applications of systems biology 3
Pendant le semestre During the semester Crédit Credits 3 Session hiver Session winter HIV HIV
Mineur en Biotechnologie, 2024-2025, Semestre automne Biotechnology minor, 2024-2025, Autumn semester Ecole polytechnique fédérale de Lausanne EPFL Ecole polytechnique fédérale de Lausanne EPFL 2024-2025 Semestre automne H HIVER Autumn semester H Mineur en Biotechnologie MIN_BIOTECH Biotechnology minor MIN_BIOTECH
optionnel optional
2 Cours Courses Heure(s) hebdo x 14 semaines Hour(s) per week x 14 weeks H hebdo H hebdo Hatzimanikatis Vassily 174688
Chimie et génie chimique CGC Chemistry and Chemical Engineering CGC
1 Exercices Exercises Heure(s) hebdo x 14 semaines Hour(s) per week x 14 weeks H hebdo H hebdo Hatzimanikatis Vassily 174688
Chimie et génie chimique CGC Chemistry and Chemical Engineering CGC
71898059 Principles and applications of systems biology Principles and applications of systems biology 3
Pendant le semestre During the semester Crédit Credits 3 Session hiver Session winter HIV HIV
Mineur en Computational biology, 2024-2025, Semestre automne Computational biology minor, 2024-2025, Autumn semester Ecole polytechnique fédérale de Lausanne EPFL Ecole polytechnique fédérale de Lausanne EPFL 2024-2025 Semestre automne H HIVER Autumn semester H Mineur en Computational biology MIN_IN_COMP_BIO Computational biology minor MIN_IN_COMP_BIO
optionnel optional
2 Cours Courses Heure(s) hebdo x 14 semaines Hour(s) per week x 14 weeks H hebdo H hebdo Hatzimanikatis Vassily 174688
Chimie et génie chimique CGC Chemistry and Chemical Engineering CGC
1 Exercices Exercises Heure(s) hebdo x 14 semaines Hour(s) per week x 14 weeks H hebdo H hebdo Hatzimanikatis Vassily 174688
Chimie et génie chimique CGC Chemistry and Chemical Engineering CGC
71898059 Principles and applications of systems biology Principles and applications of systems biology 3
Pendant le semestre During the semester Crédit Credits 3 Session hiver Session winter HIV HIV
Mineur en Physique des systèmes vivants, 2024-2025, Semestre automne Physics of living systems minor, 2024-2025, Autumn semester Ecole polytechnique fédérale de Lausanne EPFL Ecole polytechnique fédérale de Lausanne EPFL 2024-2025 Semestre automne H HIVER Autumn semester H Mineur en Physique des systèmes vivants MIN_SV_PHYS Physics of living systems minor MIN_SV_PHYS
optionnel optional
2 Cours Courses Heure(s) hebdo x 14 semaines Hour(s) per week x 14 weeks H hebdo H hebdo Hatzimanikatis Vassily 174688
Chimie et génie chimique CGC Chemistry and Chemical Engineering CGC
1 Exercices Exercises Heure(s) hebdo x 14 semaines Hour(s) per week x 14 weeks H hebdo H hebdo Hatzimanikatis Vassily 174688
Chimie et génie chimique CGC Chemistry and Chemical Engineering CGC
71898059 Principles and applications of systems biology Principles and applications of systems biology 3
Pendant le semestre During the semester Crédit Credits 3 Session hiver Session winter HIV HIV
Mineur en Science et ingénierie computationnelles, 2024-2025, Semestre automne Computational science and engineering minor, 2024-2025, Autumn semester Ecole polytechnique fédérale de Lausanne EPFL Ecole polytechnique fédérale de Lausanne EPFL 2024-2025 Semestre automne H HIVER Autumn semester H Mineur en Science et ingénierie computationnelles MIN_MA_CO Computational science and engineering minor MIN_MA_CO
optionnel optional
2 Cours Courses Heure(s) hebdo x 14 semaines Hour(s) per week x 14 weeks H hebdo H hebdo Hatzimanikatis Vassily 174688
Chimie et génie chimique CGC Chemistry and Chemical Engineering CGC
1 Exercices Exercises Heure(s) hebdo x 14 semaines Hour(s) per week x 14 weeks H hebdo H hebdo Hatzimanikatis Vassily 174688
Chimie et génie chimique CGC Chemistry and Chemical Engineering CGC
71898059 Principles and applications of systems biology Principles and applications of systems biology 3
Pendant le semestre During the semester Crédit Credits 3 Session hiver Session winter HIV HIV
Mineur en Systems Engineering, 2024-2025, Semestre automne Systems Engineering minor, 2024-2025, Autumn semester Ecole polytechnique fédérale de Lausanne EPFL Ecole polytechnique fédérale de Lausanne EPFL 2024-2025 Semestre automne H HIVER Autumn semester H Mineur en Systems Engineering MIN_SYS_ENG Systems Engineering minor MIN_SYS_ENG
optionnel optional
2 Cours Courses Heure(s) hebdo x 14 semaines Hour(s) per week x 14 weeks H hebdo H hebdo Hatzimanikatis Vassily 174688
Chimie et génie chimique CGC Chemistry and Chemical Engineering CGC
1 Exercices Exercises Heure(s) hebdo x 14 semaines Hour(s) per week x 14 weeks H hebdo H hebdo Hatzimanikatis Vassily 174688
Chimie et génie chimique CGC Chemistry and Chemical Engineering CGC
71898059 Principles and applications of systems biology Principles and applications of systems biology 3
Pendant le semestre During the semester Crédit Credits 3 Session hiver Session winter HIV HIV
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FO_fin HTML_debut &#948; HTML_fin JS_debut \x26#948; JS_fin CODE56073309 BOOLEAN_Symbol 1 BaliseJS_debut \x5bpi\x5d BaliseJS_fin Balise_debut [pi] Balise_fin FO_debut [inline]=&#960; FO_fin HTML_debut &#960; HTML_fin JS_debut \x26#960; JS_fin CODE56074095 BOOLEAN_Symbol 1 BaliseJS_debut \x5bDELTA\x5d BaliseJS_fin Balise_debut [DELTA] Balise_fin FO_debut [inline]=&#916; FO_fin HTML_debut &#916; HTML_fin JS_debut \x26#916; JS_fin CODE56074172 BOOLEAN_Symbol 1 BaliseJS_debut \x5bMU\x5d BaliseJS_fin Balise_debut [MU] Balise_fin FO_debut [inline]=&#924; FO_fin HTML_debut &#924; HTML_fin JS_debut \x26#924; JS_fin CODE56074264 BOOLEAN_Symbol 1 BaliseJS_debut \x5bPI\x5d BaliseJS_fin Balise_debut [PI] Balise_fin FO_debut [inline]=&#928; FO_fin HTML_debut &#928; HTML_fin JS_debut \x26#928; JS_fin CODE56074328 BOOLEAN_Symbol 1 BaliseJS_debut \x5bSIGMA\x5d BaliseJS_fin Balise_debut [SIGMA] Balise_fin FO_debut [inline]=&#931; FO_fin HTML_debut &#931; HTML_fin JS_debut \x26#931; JS_fin CODE56075056 BOOLEAN_Symbol 1 BaliseJS_debut \x5bALPHA\x5d BaliseJS_fin Balise_debut [ALPHA] Balise_fin FO_debut [inline]=&#913; FO_fin HTML_debut &#913; HTML_fin JS_debut \x26#913; JS_fin CODE56075186 BOOLEAN_Symbol 1 BaliseJS_debut \x5bBETA\x5d BaliseJS_fin Balise_debut [BETA] Balise_fin FO_debut [inline]=&#914; FO_fin HTML_debut &#914; HTML_fin JS_debut \x26#914; JS_fin BALISE_SYMBOL BOOLEAN_Symbol BaliseJS_debut \x5bsymbol\x5d BaliseJS_fin \x5b\x2fsymbol\x5d Balise_debut [symbol] Balise_fin [/symbol] FO_debut font-family=Symbol FO_fin font-family= HTML_debut <font style="font-family:Symbol;"> HTML_fin </font> JS_debut \x3cfont style="font-family:Symbol;"\x3e JS_fin \x3c\x2ffont\x3e CODE56072935 BOOLEAN_Symbol 1 BaliseJS_debut \x5bmu\x5d BaliseJS_fin Balise_debut [mu] Balise_fin FO_debut [inline]=&#956; FO_fin HTML_debut &#956; HTML_fin JS_debut \x26#956; JS_fin CODE56073842 BOOLEAN_Symbol 1 BaliseJS_debut \x5bsigma\x5d BaliseJS_fin Balise_debut [sigma] Balise_fin FO_debut [inline]=&#963; FO_fin HTML_debut &#963; HTML_fin JS_debut \x26#963; JS_fin CODE68199232 BOOLEAN_Symbol 1 BaliseJS_debut \x5bphi\x5d BaliseJS_fin Balise_debut [phi] Balise_fin FO_debut [inline]=&#966; FO_fin HTML_debut &#966; HTML_fin JS_debut \x26#966; JS_fin CODE68199285 BOOLEAN_Symbol 1 BaliseJS_debut \x5bPHI\x5d BaliseJS_fin Balise_debut [PHI] Balise_fin FO_debut [inline]=&#934; FO_fin HTML_debut &#934; HTML_fin JS_debut \x26#934; JS_fin CODE68199991 BOOLEAN_Symbol 1 BaliseJS_debut \x5bgamma\x5d BaliseJS_fin Balise_debut [gamma] Balise_fin FO_debut [inline]=&#947; FO_fin HTML_debut &#947; HTML_fin JS_debut \x26#947; JS_fin CODE68200031 BOOLEAN_Symbol 1 BaliseJS_debut \x5bGAMMA\x5d BaliseJS_fin Balise_debut [GAMMA] Balise_fin FO_debut [inline]=&#915; FO_fin HTML_debut &#915; HTML_fin JS_debut \x26#915; JS_fin CODE68200077 BOOLEAN_Symbol 1 BaliseJS_debut \x5bomega\x5d BaliseJS_fin Balise_debut [omega] Balise_fin FO_debut [inline]=&#969; FO_fin HTML_debut &#969; HTML_fin JS_debut \x26#969; JS_fin CODE68200150 BOOLEAN_Symbol 1 BaliseJS_debut \x5bOMEGA\x5d BaliseJS_fin Balise_debut [OMEGA] Balise_fin FO_debut [inline]=&#937; FO_fin HTML_debut &#937; HTML_fin JS_debut \x26#937; JS_fin CODE72092691 BOOLEAN_Symbol BaliseJS_debut \x5beta\x5d BaliseJS_fin Balise_debut [eta] Balise_fin FO_debut [inline]=&#951; FO_fin HTML_debut &#951; HTML_fin JS_debut \x26#951; JS_fin CODE72092805 BOOLEAN_Symbol BaliseJS_debut \x5bETA\x5d BaliseJS_fin Balise_debut [ETA] Balise_fin FO_debut [inline]=&#919; FO_fin HTML_debut &#919; HTML_fin JS_debut \x26#919; JS_fin BALISE_SOULIGNER BOOLEAN_Symbol BaliseJS_debut \x5bu\x5d BaliseJS_fin \x5b\x2fu\x5d Balise_debut [u] Balise_fin [/u] FO_debut text-decoration=underline FO_fin text-decoration=none HTML_debut <u> HTML_fin </u> JS_debut \x3cu\x3e JS_fin \x3c\x2fu\x3e CODE72092388 BOOLEAN_Symbol BaliseJS_debut \x5bpsi\x5d BaliseJS_fin Balise_debut [psi] Balise_fin FO_debut [inline]=&#968; FO_fin HTML_debut &#968; HTML_fin JS_debut \x26#968; JS_fin CODE72092541 BOOLEAN_Symbol BaliseJS_debut \x5bPSI\x5d BaliseJS_fin Balise_debut [PSI] Balise_fin FO_debut [inline]=&#936; FO_fin HTML_debut &#936; HTML_fin JS_debut \x26#936; JS_fin CODE140502511 BOOLEAN_Symbol 1 BaliseJS_debut \x5brho\x5d BaliseJS_fin Balise_debut [rho] Balise_fin FO_debut [inline]=&#961; FO_fin HTML_debut &#961; HTML_fin JS_debut \x26#961; JS_fin CODE140504636 BOOLEAN_Symbol 1 BaliseJS_debut \x5bRHO\x5d BaliseJS_fin Balise_debut [RHO] Balise_fin FO_debut [inline]=&#929; FO_fin HTML_debut &#929; HTML_fin JS_debut \x26#929; JS_fin CODE148292791 BOOLEAN_Symbol BaliseJS_debut \x5bepsilon\x5d BaliseJS_fin Balise_debut [epsilon] Balise_fin FO_debut [inline]=&#949; FO_fin HTML_debut &#949; HTML_fin JS_debut \x26#949; JS_fin CODE169976220 BOOLEAN_Symbol BaliseJS_debut \x5blig\x5d BaliseJS_fin Balise_debut [lig] Balise_fin FO_debut [inline]=&#x203A;&#160;&#160; FO_fin HTML_debut &#x203A;&#160;&#160; HTML_fin JS_debut \x26#x203A;\x26#160;\x26#160; JS_fin CODE148292899 BOOLEAN_Symbol BaliseJS_debut \x5bEPSILON\x5d BaliseJS_fin Balise_debut [EPSILON] Balise_fin FO_debut [inline]=&#917; FO_fin HTML_debut &#917; HTML_fin JS_debut \x26#917; JS_fin BALISETXT_SAUT BOOLEAN_Symbol BaliseJS_debut \x5bbr\x2f\x5d BaliseJS_fin Balise_debut [br/] Balise_fin FO_debut FO_fin HTML_debut <br/> HTML_fin JS_debut \x3cbr\x2f\x3e JS_fin 71898059 Principles and applications of systems biology Principles and applications of systems biology anglais Hatzimanikatis Vassily 174688 247681